¿Debemos prestar más atención a la creatinina baja? / Should we pay more attention to low creatinine levels?

Se revisan los aspectos básicos del metabolismo de la creatina/creatinina y la íntima relación entre la creatinina y la masa muscular, lo que la convierte en un marcador bioquímico de ésta. Se hace énfasis en la utilidad pronóstica actual, tanto de la baja excreción urinaria de creatinina como de los niveles bajos de creatinina sérica, en diferentes contextos clínicos en los que la sarcopenia probablemente desempeña un papel importante en la morbilidad y mortalidad

A review is made of the basic aspects of creatine/creatinine metabolism and the close relationship between creatinine and muscle mass, which makes the former a biochemical marker of the latter. Emphasis is placed on the current prognostic value of both the low urinary excretion of creatinine and low serum creatinine levels in different clinical settings in which sarcopenia probably plays a significant role in morbidity and mortality

Male precocious puberty described in literature of the Spanish Golden Age.

Aristotle was the first author who described the existence of abnormalities in the timing of human puberty. In the classic Greek-Roman period, Pliny the Elder and Phlegon of Tralles described the first individual cases of precocious puberty in children. During the Middle Ages, precocious puberty in the male (but not in the female) was ignored. We present what is, to our knowledge, the first full description in European literature of male precocious puberty and its consequences in an adult. This case is included in a book of the miscellaneous genre of Spanish Renaissance literature (Jardin de Flores Curiosas) written by Antonio de Torquemada in the sixteenth century.